Preeclampsia by Shigeru Saito

Author:Shigeru Saito
Language: eng
Format: epub, pdf
Publisher: Springer Singapore, Singapore

9.3.6.1 Renin Angiotensin-Related Models of Preeclampsia

Human angiotensinogen-overexpressing female mice or rats mated with human renin-overexpressing males develop transient elevated blood pressure late in pregnancy associated with proteinuria, IUGR [56–58]. These changes were thought to occur secondary to elevated secretion of placental renin. Mouse offspring with both transgenes also exhibit chronic hypertension [57].

9.3.6.2 The BPH/5 Mouse

The BPH/5 mouse strain, which is mildly hypertensive, has been discovered and used to study the relation between preexisting hypertension and preeclampsia. These mice develop preeclampsia-like symptoms, including late gestational hypertension, proteinuria, endothelial dysfunction, poor placental development, and abnormal maternal uterine arteries [59, 60]. In addition, the elevated blood pressure decreased to nonpregnancy levels 2 days after delivery. This model has been used to test potential therapeutic agents for preeclampsia. Administration of the angiogenic factor VEGF121 prevents the development of preeclampsia-like symptoms in BPH/5 mice [61]. The result indicates the potential treatment for patients with chronic hypertension.

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